Characteristics and outcomes of COVID-19 in patients with HIV: a multicentre research network study

12 octobre 2020

Source : AIDSNovember 01, 2020 – Volume 34

Auteur : Yousaf B. Hadi , Syeda F.Z. Naqvi , Justin T. Kupec and Arif R. Sarwari


OBJECTIVE

We studied clinical outcomes of COVID-19 infection in patients living with HIV (PLH) in comparison to non-HIV population.

INTRODUCTION

Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) related disease (COVID-19) has emerged as the major health crisis of 2020 [1]. Its impact on patients with preexisting infection with HIV has hitherto not been studied extensively. Recently, the Centers for Disease Control and Prevention (CDC) highlighted that patients living with HIV may be at a heightened risk of severe illness from SARS-CoV-2 as compared to the general population [2]. This postulated increased risk was attributed to both biological immune compromise and comorbidities as well as socially produced burdens. However, others have suggested that the use of antivirals in this population may confer relative protection from the virus [3]. Considering the large global burden of patients living with HIV, data on COVID-19 infection in these patients are scarce and are limited to case reports and small case series, which do not allow for comparison of outcomes with non-HIV populations [4,5]. We aimed to utilize a multicentre research network to study outcomes in patients with COVID-19 with preexisting HIV infection in comparison to those without HIV coinfection.


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